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Adoptive cell transfer therapy for hepatocellular carcinoma

Renyu Zhang, Zhao Zhang, Zekun Liu, Ding Wei, Xiaodong Wu, Huijie Bian, Zhinan Chen

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 3-11 doi: 10.1007/s11684-019-0684-x

Abstract: The antitumor activities of adoptive cell transfer therapy (ACT), such as strategies based on tumor-infiltrating

Keywords： adoptive cell transfer therapy     hepatocellular carcinoma     T cell     chimeric antigen receptor     immunotherapy    

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract:

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidly and directly kill transformed cells in the absence of antigen presensitization. Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cell lines, have been used for producing NK cells. In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did not. However, considering the safety, activities, and reliability of the cell products, researchers must develop an optimal protocol for producing NK cells from PBMCs in the manufacture setting and clinical therapeutic regimen. In this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed.

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

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Augmentation of natural convective heat transfer by acoustic cavitation

Jun CAI, Xiulan HUAI, Shiqiang LIANG, Xunfeng LI,

Frontiers in Energy 2010, Volume 4, Issue 3,   Pages 313-318 doi: 10.1007/s11708-009-0064-3

Abstract: experimental study was conducted to investigate the effects of acoustic cavitation on natural convective heat transferThe experimental results indicated that heat transfer could be enhanced by acoustic cavitation and had

Keywords： heat transfer enhancement     augmentation     acoustic cavitation     acoustic streaming     convective heat transfer    

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Experimental study of heat transfer coefficient with rectangular baffle fin of solar air heater

Foued CHABANE,Nesrine HATRAF,Noureddine MOUMMI

Frontiers in Energy 2014, Volume 8, Issue 2,   Pages 160-172 doi: 10.1007/s11708-014-0321-y

Abstract: The heat transfer coefficient between the absorber plate and air can be considerably increased by usingexperimental study has been conducted to investigate the effect of roughness and operating parameters on heat transferTo determine the enhancement in heat transfer and increment in thermal efficiency, the values of Nusselt

Keywords： Nusselt number     flow rate     heat transfer     heat transfer coefficient     thermal efficiency     forced convection    

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Effect of heat transfer space non-uniformity of combustion chamber components on in-cylinder heat transfer

Jizu LV, Minli BAI, Long ZHOU, Jian ZHOU,

Frontiers in Energy 2010, Volume 4, Issue 3,   Pages 392-401 doi: 10.1007/s11708-009-0066-1

Abstract: Based on the three-dimensional numerical simulation of the heat transfer of the coupled body, a coupledThe model was applied in the investigation of the influence of space non-uniformity in heat transferamong combustion chamber components on in-cylinder heat transfer.effect of wall temperature space non-uniform distribution of combustion chamber components on heat transferwall temperature space non-uniform distribution of combustion chamber components would influence heat transfer

Keywords： heat transfer     space non-uniformity     soot emission     in-cylinder     diesel    

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Heat transfer coefficient of wheel rim of large capacity steam turbines

SHI Jinyuan, DENG Zhicheng, YANG Yu, JUN Ganwen

Frontiers in Energy 2008, Volume 2, Issue 1,   Pages 20-24 doi: 10.1007/s11708-008-0015-4

Abstract: A way of calculating the overall equivalent heat transfer coefficient of wheel rims of large capacityThe method and formula to calculate the mean forced convection heat-transfer coefficient of the surfaceA fin heat transfer model was then used to calculate the equivalent heat transfer coefficient of theThe overall equivalent heat transfer coefficient of the wheel rim was then calculated using a cylindricalThe proposed method helps determine the heat transfer boundary conditions in finite element analyses

Keywords： convection heat-transfer     capacity     heat-transfer coefficient     bottom     transmission    

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Review of the LNG intermediate fluid vaporizer and its heat transfer characteristics

Frontiers in Energy 2022, Volume 16, Issue 3,   Pages 429-444 doi: 10.1007/s11708-021-0747-y

Abstract: In this present paper, studies of IFV and its heat transfer characteristics in the LNG vaporization unitMoreover, studies on the fluid flow and heat transfer behaviors of the supercritical LNG inside the tubesand the condensation heat transfer of the intermediate fluid outside the tubes are summarized.In the thermal calculations of the IFV, the selections of the existing heat transfer correlations aboutFurthermore, corresponding experiments or numerical simulations on the cryogenic condensation heat transfer

Keywords： intermediate fluid vaporizer     design of structure and intermediate fluid     condensation heat transfer    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans     adoptive    

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Improving hole transfer of boron nitride quantum dots modified PDI for efficient photodegradation

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 11,   Pages 1718-1727 doi: 10.1007/s11705-023-2319-7

Abstract: In recent years, organic photocatalyst under visible-light absorption has shown significant potential for solving environmental problems. However, it is still a great challenge for constructing a highly active organic photocatalyst due to the low separation efficiency of photogenerated carriers. Herein, an effective and robust photocatalyst perylene-3,4,9,10-tetracarboxylic diamide/boron nitride quantum dots (PDI/BNQDs), consisting of self-assemble PDI with π–π stacking structure and BNQDs, has been constructed and researched under visible light irradiation. The PDI/BNQDs composite gradually increases organic pollutant photodegradation with the loading amount of BNQDs. With 10 mL of BNQDs solution added (PDI/BNQDs-10), the organic pollutant photodegradation performance reaches a maximum, about 6.16 times higher with methylene blue and 1.68 times higher with ciprofloxacin than that of pure PDI supramolecular. The enhancement is attributed to improved separation of photogenerated carriers from self-assembled PDI by BNQDs due to their preeminent ability to extract holes. This work is significant for the supplement of PDI supramolecular composite materials. We believe that this photocatalytic design is capable of expanding organic semiconductors’ potential for their applications in photocatalysis.

Keywords： PDI     boron nitride     quantum dots     photocatalysis     hole transfer    

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A new heat transfer correlation for supercritical fluids

Yanhua YANG, Xu CHENG, Shanfang HUANG

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 226-232 doi: 10.1007/s11708-009-0022-0

Abstract: A new method of heat transfer prediction in supercritical fluids is presented.Assessment of qualitative behaviour of heat transfer is conducted based on existing test data and experiencesingle dimensionless number, the acceleration number, is introduced to correct the deviation of heat transferThe new correlation structure excludes direct dependence of heat transfer coefficient on wall surfaceComparison of various heat transfer correlations with the selected test data shows that the new correlation

Keywords： super critical fluids     heat transfer     circular tubes     prediction method    

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Insights into the electron transfer mechanisms of permanganate activation by carbon nanotube membrane

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1706-0

Abstract: ItemContent>

● A CNT filter enabled effective KMnO4 activation via facilitated electron transfer

Keywords： KMnO4     Carbon nanotubes     Non-radical pathway     Electron transfer     Water treatment    

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Chemically reactive solute transfer in a boundary layer slip flow along a stretching cylinder

Swati Mukhopadhyay

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 385-391 doi: 10.1007/s11705-011-1101-4

Abstract: The skin friction as well as the mass transfer rate at the surface is larger for a cylinder than for

Keywords： boundary layer     stretching cylinder     partial slip     mass transfer     similarity solution    

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Potential of electron transfer and its application in dictating routes of biochemical processes associated

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: of reduction of a compound, we have recently proposed a calculation termed as potential of electron transferEnabling electron transfer could drive metabolic reprogramming in cancer metabolism.Therefore, the concept and model established on electron transfer could guide the treatment strategies

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer    

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Studies on the liquid-liquid interfacial mass transfer process using holographic interferometry

ZHAO Chaofan, ZHU Chunying, MA Youguang

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 1,   Pages 1-4 doi: 10.1007/s11705-008-0006-3

Abstract: This paper aims at the interfacial phenomena of liquid-liquid mass transfer and its characteristic.concentration distributions on the aqueous side were obtained according to holographic diagrams of mass transferFurthermore, the concentrations near the interface and the mass transfer coefficients were attained.It is indicated that the liquid-liquid mass transfer process is approximately in accordance with two-filmthe solute, and the interface of liquid-liquid is non-equilibrium thermodynamically during the mass transfer

Keywords： liquid-liquid     different     real-time holographic     addition     transfer    

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Heat and mass transfer of ammonia-water in falling film evaporator

Xianbiao BU, Weibin MA, Huashan LI

Frontiers in Energy 2011, Volume 5, Issue 4,   Pages 358-366 doi: 10.1007/s11708-011-0161-y

Abstract: To investigate the performance of heat and mass transfer of ammonia-water during the process of fallingcan reduce the concentration gradient in the film thickness direction and enhance the heat and mass transfer

Keywords： falling film evaporation     ammonia-water     heat and mass transfer    

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Title Author Date Type Operation

Adoptive cell transfer therapy for hepatocellular carcinoma

Renyu Zhang, Zhao Zhang, Zekun Liu, Ding Wei, Xiaodong Wu, Huijie Bian, Zhinan Chen

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Augmentation of natural convective heat transfer by acoustic cavitation

Jun CAI, Xiulan HUAI, Shiqiang LIANG, Xunfeng LI,

Journal Article

Experimental study of heat transfer coefficient with rectangular baffle fin of solar air heater

Foued CHABANE,Nesrine HATRAF,Noureddine MOUMMI

Journal Article

Effect of heat transfer space non-uniformity of combustion chamber components on in-cylinder heat transfer

Jizu LV, Minli BAI, Long ZHOU, Jian ZHOU,

Journal Article

Heat transfer coefficient of wheel rim of large capacity steam turbines

SHI Jinyuan, DENG Zhicheng, YANG Yu, JUN Ganwen

Journal Article

Review of the LNG intermediate fluid vaporizer and its heat transfer characteristics

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Journal Article

Improving hole transfer of boron nitride quantum dots modified PDI for efficient photodegradation

Journal Article

A new heat transfer correlation for supercritical fluids

Yanhua YANG, Xu CHENG, Shanfang HUANG

Journal Article

Insights into the electron transfer mechanisms of permanganate activation by carbon nanotube membrane

Journal Article

Chemically reactive solute transfer in a boundary layer slip flow along a stretching cylinder

Swati Mukhopadhyay

Journal Article

Potential of electron transfer and its application in dictating routes of biochemical processes associated

Journal Article

Studies on the liquid-liquid interfacial mass transfer process using holographic interferometry

ZHAO Chaofan, ZHU Chunying, MA Youguang

Journal Article

Heat and mass transfer of ammonia-water in falling film evaporator

Xianbiao BU, Weibin MA, Huashan LI

Journal Article